Sina Doxycycline Hyclate fabrikanten en leveransiers |CPF

Doxycycline Hyclate

Koarte beskriuwing:

Namme fan API	Oanwizing	Spesifikaasje	Amerikaanske DMF	EU DMF	CEP
Doxycycline Hyclate	Antibiotika	USP/EP	13771	√

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Eftergrûn

Doxycycline hyclate is in antibiotika [1].

Doxycycline hyclate is in derivative fan tetracycline en hat de aktiviteiten fan anty-inflammatoare en antimikrobiële.Doxycycline inhibits dengue-firusreplikaasje in vitro op in temperatuer-ôfhinklike manier.De IC50-wearde is 52.3μM by 37°C en 26.7μM by 40°C.It remt it dengue-firus troch it remmen fan de NS2B-NS3 serineprotease fan it firus.60μM doxycycline ferleget de CPE fan 'e DNEV2-ynfekteare sellen [1].

Doxycycline wurdt fûn in inhibitor fan MMP.Doxycycline-behanneling ferleget MMP-8- en -9-nivo's en remt de ekspresje fan weefsel MMP-2 en MMP-9.Boppedat ferminderet behanneling mei doxycycline de ynsidinsje fan intrakraniale aneurysmen signifikant.Doxycycline is ek rapportearre as in anty-inflammatoare agint basearre op syn remming fan matrix metalloproteinases.Derneist hat doxycycline krêftige antymalariaaktiviteit mei IC50-wearde fan 320nM by 96h in vitro [2, 3].

Referinsjes:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R.Arch Virol.2014 Apr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A.Med J Islam Repub Iran.Novimber 2013;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, et al. Nelson ML.In vitro en in vivo antimalariale effektiviteit fan optimisearre tetracyclines.Antimikrobyske aginten Chemother.2013 Jul;57(7):3131-6.

Beskriuwing

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), in antibiotika, is in oraal aktive en breedspektrum metalloproteinase (MMP) inhibitor [1].

Klinyske test

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NCT01418742	Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH\|ClinAssess GmbH	Kolorektaal karsinoom	augustus 2011	Fase 2
NCT00980148	Nasjonaal Ynstitút foar Allergy en Ynfeksjesykten (NIAID)	Chlamydia ynfeksje	desimber 2009	Fase 3
NCT03342456	It tredde Xiangya sikehûs fan Central South University\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm.Ind. Co., Ltd.	Duodenale ulcer troch Helicobacter pylori	13 desimber 2017	Fase 4
NCT04310930	De Universiteit fan Queenslân\|Australian Government Department of Health\|Children's Hospital Foundation\|Cystic Fibrosis Foundation\|Newcastle University\|Griffith University\|Erasmus Medical Center\|Monash University\|Universiteit fan Kopenhagen\|Hôpital Cochin\|South Australian Health and Medical Research Institute\|Universiteit fan Melbourne\|James Cook University, Queenslân, Austraalje\|Murdoch Childrens Research Institute	Pulmonary Disease Troch Mycobacteria (Diagnose)	maart 2020	Fase 2 \| Fase 3
NCT03709459	Kirby Ynstitút\|South Australian Health and Medical Research Institute\|Monash University	STI's Previnsje	17 desimber 2019
NCT04067011	Emergent BioSolutions\|Biomedical Advanced Research and Development Authority	Anthrax	12 augustus 2019	Fase 2
NCT02844634	Britsk-Kolumbia Sintrum foar Disease Control	HIV \| Syfilis	15 mei 2018	Fase 4
NCT00647959	It bedriuw Mylan Pharmaceuticals	Sûn	maart 2006	Fase 1
NCT00170222	Medysk Sintrum Alkmaar	Chronic Obstructive Pulmonary Disease	july 2002	Fase 4
NCT03075891	Galderma	Rosacea	5 july 2017	Fase 4
NCT00031499	Nasjonaal Ynstitút foar Allergy en Ynfeksjesykten (NIAID)	Syfilis	juny 2000	Fase 3
NCT01205464	Linkoeping Universiteit	Minderheid \| Radikulêre pine \| Kognitive dysfunksje \| Paresthesia \| Parese	febrewaris 2005	Net fan tapassing
NCT01301586	De skiednis fan Nexgen Dermatologics, Inc.	ACNE VULGARIS	novimber 2010	Fase 1 \| Fase 2
NCT02305940	Imperial College Londen	Chronic Obstructive Pulmonary Disease (COPD)	july 2014	Fase 3
NCT00351182	Dong-Min Kim\|Chosun University Hospital	Skriuw Typhus	septimber 2005	Fase 3
NCT03334682	Nantes University Hospital	Akne Vulgaris	31 jannewaris 2018	Fase 3
NCT01788215	Universiteit fan Rochester	Polycystyske ovarian syndroom (PCOS) \| Unregelmjittige menstruale syklus \| Androgen oerskot	novimber 2010	Fase 3
NCT03076281	Sidney Kimmel Cancer Center at Thomas Jefferson University\|Thomas Jefferson University	Larynx \| LIP \| Orale holte \| Farynx	3 april 2017	Fase 2
NCT00439166	Hamilton Health Sciences Corporation\|The Physicians' Services Incorporated Foundation\|McMaster University	Sykte fan Alzheimer	febrewaris 2007	Fase 3
NCT02463942	University Medical Center Ljubljana\|University of Ljubljana School of Medicine, Sloveenje	Tick-borne Encephalitis	septimber 2014	Net fan tapassing
NCT00803842	Noardwestlike Universiteit	Net Lytse Cell Lung Cancer	oktober 2008	Net fan tapassing
NCT02086591	Universiteit fan Rochester	Adult Diffuse Large B-Cell Lymphoma\|Mantelcell Lymfom Wederkerend\|Lymphoma, Follicular\|Marginale Zone B-Cell Lymphoma\|Malignant Lymphoma - Lymphoplasmacytic\|Waldenstrom Macroglobulinemia\|Lyts Lymphocytic Lymphoma\|Chronic Lymphocytic Leukemia (CLL-Celllymphoma)\|	maart 2014	Fase 2
NCT03980223	Universiteit fan Kalifornje, San Francisco\|Universiteit fan Washington\|Nasjonaal Ynstitút foar Allergy en Ynfeksjesykten (NIAID)\|Mayne Pharma International Pty Ltd\|San Francisco Department of Public Health	Gonorroe \| Chlamydia \| Syfilis	26 novimber 2019	Fase 4
NCT00355459	University of Texas Southwestern Medical Center	Syndroam fan droege eagen	augustus 2005	Net fan tapassing
NCT01254799	Omar Mamdouh Shaaban\|Assiut University	Uterine bloeding	Jannewaris 2008	Fase 3
NCT01547325	NanoSHIFT LLC\|Feriene Steaten fan Definsje	Dehisced sjirurgyske wûnen	Mei 2012	Net fan tapassing
NCT00653380	Par Pharmaceutical, Inc.\|Anapharm	Om bioekwivalinsje te bepalen ûnder fêste betingsten	septimber 1999	Fase 1
NCT00635609	Warner Chilcott	Akne Vulgaris	maart 2008	Fase 4
NCT03765931	Institut de Recherche pour le Developpement	Koarts	july 2016	Fase 4
NCT01160640	Harold Wiesenfeld\|National Institute of Allergy and Infectious Diseases (NIAID)\|University of Pittsburgh	Pelvic Inflammatory Disease	novimber 2010	Fase 2
NCT01756833	Universiteit fan Marylân, Baltimore \| Nasjonaal Ynstitút foar Aging (NIA)	Aneurysma	Mei 2013	Fase 2
NCT00688064	Galderma	Swiere akne Vulgaris	augustus 2008	Fase 3
NCT01320033	Galderma	Akne Vulgaris	29 maart 2011	Fase 2
NCT03397004	St. Michael's Hospital, Toronto\|Barrow Neurological Institute\|Duke University\|Feinstein Institute for Medical Research\|University of Pittsburgh\|Sunnybrook Health Sciences Center	Hereditary Hemorrhagic Telangiectasia (HHT)	12 septimber 2018	Fase 2
NCT01635530	Turku University Hospital	Lyme neuroborreliosis	augustus 2012	Fase 4
NCT03727620	Mohammed V Souissi Universiteit	Agressive parodontitis	6 jannewaris 2014	Fase 1 \| Fase 2
NCT02688738	Rothman Institute Orthopedics	Propionibacterium	maart 2015	Net fan tapassing
NCT00358462	Universiteit fan Washington \| Nasjonaal Ynstitút foar Allergy en ynfeksjesykten (NIAID)	Urethritis	Jannewaris 2007	Fase 3
NCT02864550	Britsk-Kolumbia Sintrum foar Disease Control	Syfilis\|Seksueel oerdraachbere ynfeksjes	15 augustus 2019	Fase 4
NCT01595594	Universiteit fan Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Parodontale sykte \| Diabetes fan type 2	maart 2010	Fase 3
NCT00964834	PharmAthene, Inc.\|National Institutes of Health (NIH)\|Medarex\|Quintiles, Inc.\|Department of Health and Human Services	Anthrax	july 2009	Fase 1
NCT01809444	Sun Yat-sen Universiteit	Thyroid Associated Opthalmopathies	novimber 2012	Fase 2 \| Fase 3
NCT01590082	MD Anderson Cancer Center \| National Institutes of Health (NIH) \| National Cancer Institute (NCI)	Melanoom	novimber 2012	Fase 1 \| Fase 2
NCT00207584	Sintrum foar syktekontrôle en previnsje	Mycoplasma Pneumoniae	Jannewaris 1994	Net fan tapassing
NCT00775177	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	Sûn	juny 2005	Net fan tapassing
NCT03462329	University Medical Center Ljubljana	Erythema Migrans	1 juny 2018	Net fan tapassing
NCT00000403	Indiana University \| Nasjonaal Ynstitút foar Arthritis en Musculoskeletale en Skin Diseases (NIAMS) \| Nasjonaal Ynstitút foar Aging (NIA)	Osteoarthritis	septimber 1996	Fase 3
NCT03508232	University of Alberta\|Royal Alexandra Hospital	ST Segment Elevation Myocardial Infarction\|Hertfal	6 jannewaris 2020	Fase 2
NCT02553473	Sorlandet Sikehûs HF	Neuroborreliosis, Borrelia Burgdorferi	oktober 2015	Fase 3
NCT02207556	Medical College of Wisconsin	Primêre systemyske amyloidosis	1 oktober 2014	Fase 2
NCT01783106	Royal Liverpool University Hospital\|Nasjonale Feriening foar Colitis en Crohn's Disease\|Nasjonaal Ynstitút foar sûnensûndersyk, Feriene Keninkryk	Crohn's Disease	1 febrewaris 2014	Fase 2
NCT00353743	Hospital de Clinicas de Porto Alegre	Abortus, Septic	Mei 2006	Net fan tapassing
NCT01727973	Sun Yat-sen Universiteit	Graves Oftalmopathy	oktober 2012	Fase 1 \| Fase 2
NCT00857038	Medysk Sintrum Alkmaar\|Leiden University Medical Center\|Universiteit fan Amsterdam	Chronic Obstructive Pulmonary Disease \| Untstekking \| Pulmonary emfyseem	april 2009	Fase 4
NCT02774993	National University Hospital, Singapore\|Tan Tock Seng Hospital\|National University, Singapore\|A*Star	Tuberkuloaze	septimber 2015	Fase 2
NCT03474458	IRCCS Policlinico S. Matteo	Cardiac AL Amyloidosis	11 febrewaris 2019	Fase 2 \| Fase 3
NCT02874430	Sidney Kimmel Cancer Center at Thomas Jefferson University\|Thomas Jefferson University	Breast Carcinoma \| Endometrial Clear Cell Adenocarcinoma \| Endometrial Serous Adenocarcinoma \| Uterine Corpus Cancer \| Uterine Corpus Carcinosarcoma	8 juny 2016	Fase 2
NCT00016835	Universiteit fan Michigan \| Nasjonaal Ynstitút foar Dental and Craniofacial Research (NIDCR)	Parodontale sykte \| Diabetes mellitus, type 2	17 oktober 2001	Fase 2
NCT00064766	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Endometriale bloeden \| Periodontale sykte	febrewaris 2003	Fase 4
NCT00803452	Universiteit fan Louisville	Blefaritis	july 2008	Fase 4
NCT01434173	Bayer\|RTI Health Solutions	Drug-Induced Lever Injury	july 2001
NCT00126204	Barnes-Joadske sikehûs	Aorta-aneurysma	maart 2004	Net fan tapassing
NCT01917721	Hawaii Pacific Health	Kawasaki Disease \| Coronary Aneurysma	oktober 2013	Fase 2
NCT02775695	Medical College of Wisconsin	Resectable pancreaskanker	3 april 2017	Fase 2
NCT03824340	Aljazeera sikehûs	Infertility	30 jannewaris 2019	Net fan tapassing
NCT01847976	Ottawa Hospital Research Institute \| Canadian Breast Cancer Foundation	Pine	augustus 2013	Fase 2
NCT02850913	Makerere University \| Universiteit fan Oxford	Anfallen	5 septimber 2016	Fase 2
NCT00764361	NanoSHIFT LLC	Diabetyske foetulcer	Jannewaris 2009	Fase 2
NCT02036528	De bedriuw Royer Biomedical, Inc.	Diabetyske foetulcers	Jannewaris 2014	Fase 1 \| Fase 2
NCT01661985	Östergotland County Council, Sweden\|Statens Serum Institut	Urethritis \| Cervicitis \| Genitale mycoplasma-ynfeksje \| Chlamydia trachomatis	febrewaris 2010	Fase 4
NCT01380483	Par Pharmaceutical, Inc.\|Anapharm	Om bioekwivalinsje te bepalen ûnder fêste betingsten	Jannewaris 2000	Fase 1
NCT00648180	It bedriuw Mylan Pharmaceuticals	Sûn	july 2005	Fase 1
NCT01426269	Galderma Laboratories, LP	Rosacea	septimber 2011	Fase 4
NCT02753426	Universiteit fan Kalifornje, San Francisco	Chronic Nier Disease \| Cardiorenal Syndrome	april 2016	Fase 1
NCT02583282	Postgraduate Institute of Medical Education and Research	Maligne Pleural Effusion	1 augustus 2015	Net fan tapassing
NCT02927496	De Task Force foar Global Health \| Feriene Steaten Agency for International Development (USAID)	Lymfoedema \| Lymfatyske filariasis \| Filariasis	19 juny 2018	Fase 3
NCT00652795	Par Pharmaceutical, Inc.\|Anapharm	Om bioekwivalinsje te bepalen ûnder fêste betingsten	july 2004	Fase 1
NCT03956212	University Medical Center Ljubljana\|University of Ljubljana School of Medicine, Sloveenje	Erythema Migrans	1 juny 2017	Net fan tapassing
NCT00855595	Bayer	Papulopustular Rosacea	febrewaris 2009	Fase 4
NCT03457636	Derm Research, PLLC	Jeugdpûkels	19 maart 2018	Fase 4
NCT02894268	Sir Run Run Shaw Sikehûs	Helicobacter pylori-ynfeksje	febrewaris 2016	Fase 4
NCT03465774	MD Anderson Cancer Center \| National Cancer Institute (NCI)	Maligne Pleural Effusion	8 maart 2018	Iere faze 1